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The Kiryūin Manor is the residence of the Kiryūin family. The Original Life Fiber is located within a secret chamber in the manor.
In Episode 18, Mitsuzō Soroi, Shirō Iori, and the Sewing Club infiltrate the manor in order to destroy the Original Life Fiber. The mission ended in a failure causing Mitsuzō, Shirō, and the remaining Sewing Club members to retreat.